*1901: New ward building constructed at intersection of Sixth and Cherokee.
*1901: Insane Ward opens. The building's still being used today for mental health and substance abuse programs.
*June 19, 1901: Patients from 1873 Arapahoe County Hospital moved out and plans are made to demolish original structure.
*1902: Arapahoe County is split up into three pieces: City and County of Denver, Adams County and Arapahoe County. The hospital is supposed to be transferred to city but county officials litigate and the hospital remains under county control until 1911.
*1904: Robert Speer elected mayor. Initiates many projects to beautify city, including Civic Center.
*1909: Steele Memorial Hospital gets major overhaul, including two new cottages and new administration building.
*1910: Roughly 630 patients forcibly interned at Sand Creek smallpox hospital.
*1910: New ward building, which is mirror image of 1901 facility, erected at corner of Sixth and Bannock.
*November 1911: The Arapahoe County Hospital passes into the hands of City and County of Denver. Operating costs were $96,553 and there were 333 patients hospitalized.
*1912: Mayor Henry Arnold replaces "Boss" Speer and sends roughly 100 alleged hangers-on at hospital Poor Farm.
*1913: The daily cost of taking care of a patient was about 70 cents.
*May 14, 1918: Mayor Robert Speer dies.
*September 27, 1918: Denver's first victim of Spanish Flu dies.
*1921: Construction of H-shaped hospital for TB sufferers is constructed across from the hospital complex at 7th and Cherokee.
*1922: Denver is in the midst of virulent smallpox epidemic. Mandatory vaccination goes into effect.
*1923: Benjamin Stapleton elected mayor.
*1923: Dr. William Sharpley retires and George "Crowbar" Collins, former Speer lieutenant, has the task of rebuilding the hospital.
*January 1924: County Hospital renamed Denver General Hospital.
*1924: Hospital undergoes complete renovation. All Health Department activities moved from City Hall to Denver General Hospital, thus centralizing health and charitable activities.
*December 22, 1927: Students move into new Nurses Home located at Eighth and Cherokee.
*1927: Conversion of Insane Ward into modern medical building.
*Late 1920's-1930's: Justina Ford, Denver's only female African American physician for fifty years, on staff at Denver General.
*May 1931: A two-story operating pavilion with amphitheater opens on Sixth Avenue. On the ground floor were two emergency rooms and a poison treatment room. Five tiled operating rooms were located on the second floor.
*December 27, 1933: Jacob Kiter, a resident at the Poor Farm, shoots and kills Harold Moore, the farm superintendent.
*1936: Nine of the hospital's 17 outpatient clinics closed due to the economy.
*1940: Three more floors and two, five-story towers were added to the operating pavilion. It was renamed the Nicholson building because $143,000 of funding came from the estate of U.S. Senator Samuel D. Nicholson. Another $117,000 came from the Works Progress Administration.
*1940: The Robert Speer Memorial Hospital for Children opens. This facility, located on Bannock, was constructed with the help of a $106,000 bequest from the estate of gambler Vaso Chucovich who wanted to erect a memorial to his old friend, Mayor Robert Speer.
*1947: Quigg Newton elected mayor and Florence Sabin appointed as manager of Health and Charity.